在治疗耐抗菌素感染中,以及无疑在降低免疫缺乏病人的细菌感染中,人免疫球蛋白(IgG)是有价值的。然而,用低温乙醇法从人血浆制备的IgG只能限于肌肉常规注射,因为在静脉输注时和输注后能发生严重的类过敏性反应。这些副作用已被归因于在分离过程形成的聚合IgG所引起的非特异性补体激活和某些杂质,诸如PKA。聚合物 Human immunoglobulins (IgG) are valuable in the treatment of antibiotic-resistant infections and, doubtless, bacterial infections in immunocompromised patients. However, IgG prepared from human plasma by the low-temperature ethanol method can only be administered to a regular muscle injections since severe anaphylactic reactions occur during and after infusion. These side effects have been attributed to nonspecific complement activation and certain impurities such as PKA caused by the polymerized IgG formed during the isolation. polymer