HIV整合酶可催化病毒复制周期中的整合过程,即将HIV反转录产物cDNA整合入宿主基因组,它是病毒复制过程不可缺少的酶。抑制该酶活性将能有效抗HIV,迄今尚未在人体内发现整合酶的功能类似物,故整合酶成为抗HIV的理想靶点。本文综述了近年来整合酶的结构、催化活性及影响因素、整合酶抑制剂的研究进展。 HIV integrase catalyzes the integration process in the viral replication cycle by integrating HIV reverse transcription product cDNA into the host genome, which is an essential enzyme in viral replication. Inhibition of this enzyme activity will be effective against HIV, so far no functional analogs of integrase have been found in humans, so integrase has become an ideal target for anti-HIV. This review summarizes the structure, catalytic activity and influencing factors of integrase in recent years and the progress of integrase inhibitors.