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目的:观察芪芎茜根散治疗小儿紫癜性肾炎的临床疗效及其对患儿免疫三项与淋巴细胞免疫的影响。方法:选取2013年6月~2015年1月淮安市第一人民医院收治的过敏性紫癜性肾炎(HSPN)患儿60例为研究对象,采用随机数表法分为治疗组和对照组各30例,治疗组给予芪芎茜根散,对照组给予口服潘生丁、复方芦丁,均治疗2个月,另选取20例健康儿童纳入空白组,观察两组患儿临床疗效,比较其尿畸形红细胞及免疫三项,同时分析血清淋巴细胞表达水平变化,并随访6个月,观察患儿复发率及呼吸道感染情况。结果:治疗组治疗有效率86.67%明显高于对照组63.33%(P<0.05);治疗后治疗组尿畸形红细胞(13.27±1.56)%、IgA(1.62±0.19)g/L、IgG(10.17±1.29)g/L低于对照组(P<0.05),IgM(2.38±0.37)g/L高于对照组(P<0.05);治疗前治疗组与对照组CD_3~+、CD_4~+、CD_4~+/CD_8~+低于空白组(P<0.05),CD_8~+、CD_(19)~+均较空白组高(P<0.05),治疗后治疗组CD_3~+、CD_4~+、CD_4~+/CD_8~+较对照组明显升高(P<0.05),CD_8~+、CD_(19)~+较对照组显著下降(P<0.05),且治疗组上述指标与空白组比较无显著差异(P>0.05);治疗组复发率3.33%低于对照组23.33%;两组不良反应发生率10.00%、6.67%比较差异无统计学意义(P>0.05)。结论:芪芎茜根散能有效缓解紫癜性肾炎患儿中医症候,改善其免疫功能,复发率低,值得在临床推广应用。
Objective: To observe the curative effect of qixiongqixianza on infantile purpura nephritis and its influence on three kinds of immunity and lymphocyte immunity in children. Methods: Sixty children with Henoch-Schonlein purpura nephritis (HSPN) who were treated in Huai’an First People’s Hospital from June 2013 to January 2015 were selected as study objects. The random number table was divided into 30 cases For example, the treatment group given Qixiang Qiangen powder, the control group given oral dipyridamole, compound rutin, were treated for 2 months, another 20 healthy children into the blank group, the clinical efficacy of two groups were observed, compared with urinary malformations of red blood cells And immune three, at the same time analysis of changes in serum levels of lymphocytes, and follow-up of 6 months, observe the recurrence rate and respiratory infections in children. Results: The effective rate of treatment group was 86.67%, which was significantly higher than that of control group (63.33%, P <0.05). After treatment, urinary malformation erythrocytes (13.27 ± 1.56)%, IgA 1.29) g / L was lower than that of the control group (P <0.05), IgM was 2.38 ± 0.37g / L higher than that of the control group (P <0.05) CD_8 ~ + and CD_ (19) ~ + in the treatment group were higher than those in the blank group (P <0.05). After the treatment, the levels of CD_3 ~ +, CD_4 ~ +, CD_4 CD_8 ~ + and CD_ (19) ~ + in the treatment group were significantly lower than those in the control group (P <0.05), and there was no significant difference between the treatment group and the blank group (P> 0.05). The relapse rate of the treatment group was 3.33% lower than that of the control group (23.33%). There was no significant difference between the two groups in the incidence of adverse reactions of 10.00% and 6.67% (P> 0.05). Conclusion: Qixiong Qian Root Powder can effectively relieve the symptoms of TCM in children with purpura nephritis and improve its immune function with low recurrence rate, which is worthy of clinical application.