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目的观察法舒地尔联合山莨菪碱治疗Ⅱ级以上糖尿病足的临床疗效。方法将29例糖尿病足患者随机分为治疗组17例和对照组12例。对照组给予常规治疗,治疗组在对照组基础上采用山莨菪碱联和法舒地尔全身静脉滴注治疗,比较2组临床疗效,空腹血糖和餐后2h血糖。结果治疗组总有效率为94.1%高于对照组的41.7%,差异有统计学意义(P<0.01)。治疗组在治疗后空腹血糖(6.9±3.2)mmol/L,餐后2h血糖(10.1±2.8)mmol/L;对照组治疗后空腹血糖(7.1±2.6)mmol/L,餐后2h血糖(9.8±2.7)mmol/L,2组空腹血糖、餐后2h血糖差异无统计学意义(P>0.05)。结论法舒地尔联合山莨菪碱用药治疗糖尿病足明显优于常规治疗效果,值得临床推广应用。
Objective To observe the clinical efficacy of fasudil combined with anisodamine in the treatment of grade Ⅱ diabetic foot. Methods Twenty-nine patients with diabetic foot were randomly divided into treatment group (n = 17) and control group (n = 12). The control group was given routine treatment. The treatment group was treated with intravenous anisodamine and fasudil intravenously on the basis of the control group. The clinical curative effect, fasting blood glucose and postprandial 2h blood glucose were compared between the two groups. Results The total effective rate of the treatment group was 94.1% higher than that of the control group (41.7%), the difference was statistically significant (P <0.01). After treatment, the fasting blood glucose (7.1 ± 2.6) mmol / L, postprandial blood glucose 2h (9.8 ± 3.2) mmol / L and postprandial blood glucose ± 2.7) mmol / L, there was no significant difference in fasting blood glucose and 2h postprandial blood glucose between the two groups (P> 0.05). Conclusion Fasudil combined with anisodamine in the treatment of diabetic foot was significantly better than the conventional treatment, worthy of clinical application.