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目的:探讨MFN2和Survivin在不同卵巢组织中的表达及意义。方法:用免疫组化法检测MFN2和Survivin在正常卵巢组织、良性卵巢肿瘤、恶性卵巢癌组的表达情况。结果:①MFN2阳性染色主要位于细胞浆,呈棕黄色颗粒,MFN2在恶性卵巢癌组表达率呈上升趋势,差异均有统计学意义(P<0.05)。②Survivin阳性染色主要位于细胞核,呈棕黄色颗粒,Sur-vivin在恶性卵巢癌组表达率呈上升趋势,差异均有统计学意义(P<0.05)。结论:MFN2和Survivin在恶性卵巢癌组织中表达较高。
Objective: To investigate the expression and significance of MFN2 and Survivin in different ovarian tissues. Methods: The expressions of MFN2 and Survivin in normal ovarian tissue, benign ovarian tumor and malignant ovarian cancer were detected by immunohistochemistry. Results: ①MNF2 positive staining was mainly located in the cytoplasm with brownish yellow granules. The expression of MFN2 in malignant ovarian cancer group showed an upward trend (P <0.05). Survivin positive staining was mainly located in the nucleus, showing brown granules, Sur-vivin expression in malignant ovarian cancer group showed an upward trend, the difference was statistically significant (P <0.05). Conclusion: MFN2 and Survivin are highly expressed in malignant ovarian cancer.