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目的 :探讨国产尿激酶 (UK)对老年急性下肢静脉血栓形成 (DVT)治疗的临床疗效和安全性。方法 :1996年 6月～1998年 6月 ,对 12例老年 DVT患者采用 U K溶栓治疗 ,首剂量 UK 10 0万 IU加入 NS 5 0 0 m l iv gtt,次日起 UK 5 0万 IU溶于 NS2 5 0 ml iv gtt维持 6 d,共 7d为一疗程。治疗期间每天监测凝血酶原时间 (PT)值 ,溶栓前后检查 BU N、Cr、WBC、BPC、Bt、Ct、纤维蛋白 (Fg)等指标 ,并作下肢腿围周径差的测量和多普勒超声的随访检测以评判疗效。结果 :U K治疗老龄急性DVT的有效率 91.7% ,优良率 5 0 % ;超声检查 :血栓溶解 9.0 % ,改善 81.8% ,无变化 9.0 % ;溶栓后 Fg明显降低 (P<0 .0 1) ,PT显著延长 (P<0 .0 1)。用药期间未发现出血、低血压等严重不良反应。结论 :UK为治疗老龄急性 DVT的安全、有效药物
Objective: To investigate the clinical efficacy and safety of domestic urokinase (UK) in the treatment of acute lower extremity venous thrombosis (DVT) in the elderly. Methods: From June 1996 to June 1998, 12 elderly patients with DVT were treated with UK thrombolytic therapy. The first dose of UK 10 000 IU was added to NS 500 ml iv, the next day UK 50 000 IU was dissolved in NS2 5 0 ml iv gtt for 6 days, a total of 7d for a course of treatment. Prothrombin time (PT) was monitored every day during treatment, BU N, Cr, WBC, BPC, Bt, Ct and Fg were measured before and after thrombolysis. Pulsed ultrasound follow-up testing to assess the efficacy. Results: The effective rate of UK was 91.7% and the excellent and good rate was 91.0%. The ultrasonography showed that the thrombolytic rate was 9.0%, improved by 81.8% and no change by 9.0%. The Fg decreased significantly after thrombolysis (P <0.01) , PT was significantly prolonged (P <0. 01). No bleeding, hypotension and other serious adverse reactions were found during the treatment. Conclusion: UK is a safe and effective drug for the treatment of acute DVT in elderly patients