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在象休克和心跳骤停这样的低血流量状态下,酸碱平衡和氧合是影响救治成功的重要因素。研究显示在心肺复苏时,CO_2分压(Pco_2)是影响pH值的主要因素,这时动脉血常呈碱性而混合静脉血(MV)则为酸性,动静脉血间的Pco_2的梯度明显增加。本实验采用循环和呼吸双控制动物模型,研究低血流量时通气对酸碱平衡和氧合作用的影响。动物用10只体重43至102公斤的当地猪,麻醉后,行气管切开插管,呼吸机辅助呼吸,持续记录呼气末CO_2浓度;行动静脉插管,持续监测血液动力学指标,停跳心脏后建立体外循环。在血流量为心脏停跳前
In low blood flow states like shock and cardiac arrest, acid-base balance and oxygenation are important factors that influence the success of treatment. Studies have shown that during cardiopulmonary resuscitation, the CO 2 partial pressure (Pco_2) is a major factor affecting the pH value. In this case, the arterial blood is alkaline and the mixed venous blood (MV) is acidic. The gradient of Pco_2 between arteriovenous and venous blood is significantly increased . In this study, a dual animal model of circulation and respiration was used to study the effects of ventilation on acid-base balance and oxygenation during periods of low blood flow. Animals with 10 pigs weighing 43 to 102 kg were anesthetized, tracheotomized intubated, ventilator-assisted breathing, continuous recording end-tidal CO 2 concentration; intravenous catheter operations, continuous monitoring of hemodynamic parameters, stop jumping Cardiac set up after cardiopulmonary bypass. Before the blood flow to cardiac arrest