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目的研究宫颈上皮内瘤变及宫颈癌患者人乳头瘤病毒基因型及病毒载量的变化情况。方法选取2015年1月-2016年6月期间南阳医专第二附属医院诊治的78例宫颈癌患者为A组,78例宫颈上皮内瘤变患者为B组,另选78名同龄健康人员为C组,检测人乳头瘤病毒基因型及HPV DNA载量,比较不同组中人乳头瘤病毒基因型及HPV DNA载量。结果宫颈癌患者(A组)HPV16、HPV18、HPV33检出率分别为88.46%、73.08%、32.05%,明显高于其它两组,差异均有统计学意义(均P<0.05),但在宫颈上皮内瘤变患者(B组)HPV6/11检出率14.10%,其它两组没有检出。HPV DNA载量方面,三组间差异有统计学意义(F=3 147.12,P<0.05),同时A组中不同宫颈癌分期及B组中不同宫颈上皮内瘤变分级患者的HPV DNA载量差异有统计学意义(均P<0.05)。结论宫颈上皮内瘤变及宫颈癌患者人乳头瘤病毒基因型及病毒载量明显异于健康同龄妇女,且宫颈癌分期与宫颈上皮内瘤变分期对其表达也有较大影响,应重视上述指标的监测。
Objective To study the changes of genotype and viral load of human papillomavirus in patients with cervical intraepithelial neoplasia and cervical cancer. Methods 78 cases of cervical cancer diagnosed and treated by the Second Affiliated Hospital of Nanyang Medical College from January 2015 to June 2016 were selected as group A, 78 cases of cervical intraepithelial neoplasia were selected as group B, and 78 healthy subjects of the same age were selected as In group C, HPV genotypes and HPV DNA loads were detected. HPV genotypes and HPV DNA loads in different groups were compared. Results The detection rates of HPV16, HPV18 and HPV33 in patients with cervical cancer (group A) were 88.46%, 73.08% and 32.05%, respectively, which were significantly higher than those in the other two groups (all P <0.05) Intraepithelial neoplasia patients (group B) HPV6 / 11 detection rate of 14.10%, the other two groups were not detected. HPV DNA load, the difference between the three groups was statistically significant (F = 3 147.12, P <0.05), at the same time A group of different cervical cancer staging and group B different cervical intraepithelial neoplasia in patients with HPV DNA load The difference was statistically significant (all P <0.05). Conclusions The genotype and viral load of human papillomavirus in patients with cervical intraepithelial neoplasia and cervical cancer are significantly different from those of healthy women, and the stage of cervical cancer and cervical intraepithelial neoplasia have a greater impact on their expression, so we should pay attention to these indicators Monitoring.