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目的 分析HLA Ⅱ类基因与狼疮性器官、系统损害的相关性 ,探讨系统性红斑狼疮(SLE)从基因到临床表达的发病机制。方法 应用PCR SSOPH技术检测 113例确诊SLE病人的DR、DQA1、DQB1等位基因。结果 浆膜炎与DQB1 0 6 0 1正相关 ;神经精神症状与DRB1 15 0 1正相关 ;血肌酐增高与DQB1 0 30 2、DQB1 0 40 1正相关 ;血尿素氮增高与DQB1 0 2 0 1负相关 ;蛋白尿与DQB1 0 30 1、DRB3 0 2 0 2、DRB3 0 30 1、DRB1 110 1负相关 ;血尿与DQB1 0 30 1、DRB3 0 30 1负相关 ;管型尿与DRB1 0 30 2正相关 ;贫血和白细胞减少分别与DQB1 0 2 0 1正相关 ;血小板减少与DRB1 15 0 2和DRB1 12 0 2正相关 ;淋巴细胞减少与DRB1 0 30 2正相关 ;C3降低与DQB1 0 30 3正相关 ,与DQB1 0 30 1负相关 ;狼疮细胞阳性与DRB1 15 0 1负相关。结论 多个HLA Ⅱ类等位基因和SLE的临床表达有相关性 ,国人的SLE遗传背景与其他人种有所不同。
Objective To analyze the association between HLA class II genes and systemic lupus erythematosus (OS) and the pathogenesis of systemic lupus erythematosus (SLE) from gene to clinical expression. Methods PCR SSOPH was used to detect the DR, DQA1 and DQB1 alleles in 113 SLE patients diagnosed. Results Serositis was positively correlated with DQB1 0 6 0 1; neuropsychiatric symptoms were positively correlated with DRB1 15 0 1; serum creatinine was positively correlated with DQB1 0 30 2 and DQB1 0 40 1; blood urea nitrogen increased with DQB1 0 2 0 1 Negative correlation between proteinuria and DQB1 0 30 1, DRB3 0 202, DRB3 0 30 1, DRB1 110 1; hematuria negatively correlated with DQB1 0 30 1 and DRB3 0 30 1; Positive correlation between anemia and leukopenia and DQB1 0 2 0 1 respectively; thrombocytopenia was positively correlated with DRB1 15 0 2 and DRB1 12 0 2; lymphopenia was positively correlated with DRB1 0 30 2; C3 decreased with DQB1 0 30 3 Positive correlation, negative correlation with DQB1 0 30 1; positive correlation between lupus and DRB1 15 0 1 negative. Conclusions There is a correlation between multiple HLA class II alleles and clinical manifestations of SLE. The genetic background of SLE in China is different from other races.