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目的探讨Tiam1和MTA1在喉鳞癌组织中的表达及其与临床病理特征的关系。方法采用免疫组化方法检测46例喉鳞癌组织及10例癌旁正常组织中Tiam1和MTA1的表达。结果 Tiam1和MTA1在喉鳞癌组织中的表达明显高于癌旁正常组织(P<0.01)。在喉癌组织中Tiam1的表达与肿瘤的临床分期及有无淋巴结转移有关,而与患者的年龄、性别及肿瘤的病理分级无关。MTA1的表达与肿瘤的临床分期、病理分级及有无淋巴结转移有关,而与患者的年龄、性别无关。喉癌组织中Tiaml蛋白与MTA1蛋白的表达呈正相关。结论Tiam1和MTA1可能与喉鳞癌的侵袭、转移相关,对喉癌的诊断、治疗和预后具有重要参考意义。
Objective To investigate the expression of Tiam1 and MTA1 in laryngeal squamous cell carcinoma and its relationship with clinicopathological features. Methods Immunohistochemistry was used to detect the expression of Tiam1 and MTA1 in 46 cases of laryngeal squamous cell carcinoma and 10 cases of adjacent normal tissues. Results The expression of Tiam1 and MTA1 in laryngeal squamous cell carcinoma tissues was significantly higher than that in adjacent normal tissues (P <0.01). The expression of Tiam1 in laryngeal carcinoma was related to the clinical stage and lymph node metastasis, but not to the age, sex and the pathological grade of the tumor. MTA1 expression and clinical stage, pathological grade and lymph node metastasis, but not with the patient’s age and gender. The expression of Tiaml protein and MTA1 protein in laryngeal carcinoma was positively correlated. Conclusions Tiam1 and MTA1 may be related to the invasion and metastasis of laryngeal squamous cell carcinoma, which is of important reference value for the diagnosis, treatment and prognosis of laryngeal carcinoma.