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我国大部分慢性乙肝患者是在围生产期及婴幼儿期感染乙肝病毒的,为此,2010年版《慢性乙型肝炎防治指南》根据近年来的研究成果,把乙肝病毒感染的自然史分为:免疫耐受期、免疫清除期、非活动或低(非)复制期和再活动期。了解慢性乙肝病毒感染的自然史,可以使我们对乙肝病毒的感染有更为深刻的认识,有利于掌握治疗的最佳时机。
Most chronic hepatitis B patients in our country are infected with hepatitis B virus during the perinatal and infancy stages. Therefore, the 2010 edition of “Guidelines for the Prevention and Treatment of Chronic Hepatitis B” classified the natural history of hepatitis B virus infection according to the research results in recent years: Immune tolerance, immunosuppression, inactive or low (non) replication and reactivation. Understanding the natural history of chronic hepatitis B virus infection can make us have a deeper understanding of the hepatitis B virus infection and help to grasp the best time for treatment.