论文部分内容阅读
本文综合报道了对Hilltop(HT)大鼠和Wistar (W)大鼠缺氧性肺血管收缩反应(HPV)的研究。观察抑制白三烯(LTs)或前列腺素(PGs)合成对HPV和慢性缺氧性肺动脉高压产生的影响,以及测定急性缺氧时血浆TXB_2和6-酮-PGF1α的变化,均表明LTs是两种大鼠HPV的主要介质,HT鼠还有缩管性PGs参与介导,而W鼠则受扩管性PGs调节;加之肺小动脉结构的差别,构成了两种大鼠肺血管反应性差异的主要原因。
This article reports on hypoxic pulmonary vasoconstriction (HPV) in Hilltop (HT) and Wistar (W) rats. To observe the effects of inhibition of leukotrienes (LTs) or prostaglandins (PGs) synthesis on HPV and chronic hypoxic pulmonary hypertension, as well as the changes of plasma TXB2 and 6-keto-PGF1α in acute hypoxia, both showed that LTs were two The main mediators of rat type HPV, HT rats and scrotal PGs were involved in mediation, while W rats were regulated by expansile PGs. Combined with the structure of pulmonary arterioles, they formed the pulmonary vascular reactivity difference The main reason.