论文部分内容阅读
目的研究在不同pH值人工胃液和人工肠液中蒙脱石散对常与其配伍药物诺氟沙星、氧氟沙星、萸连片、雷尼替丁、法莫替丁、阿昔洛韦、利巴韦林的体外吸附作用。方法取蒙脱石散分别加入到用不同pH人工胃液和人工肠液溶解的上述药物溶液中,用高效液相色谱法测定药物含量,计算吸附率。结果蒙脱石对萸连片中巴马汀、小檗碱的吸附率达95%以上;对诺氟沙星、氧氟沙星吸附率达80%左右;对阿昔洛韦、利巴韦林吸附率比较小,在10%以下;对法莫替丁和雷尼替丁的吸附率随着pH值的增加而降低。结论蒙脱石散对上述药物有不同的吸附作用,吸附率大的药物配伍应用时注意服药间隔时间。
OBJECTIVE To study the effect of montmorillonite powder in combination with norfloxacin, ofloxacin, cornelian, ranitidine, famotidine, acyclovir, Adsorption of ribavirin in vitro. Methods Montmorillonite powders were added to the above drug solutions dissolved in different pH artificial gastric juice and artificial intestinal juice respectively. The drug content was determined by HPLC and the adsorption rate was calculated. Results The adsorption rate of montmorillonite to palmatine and berberine reached more than 95%. The adsorption rate to norfloxacin and ofloxacin was about 80%. For acyclovir, The adsorption rate of forest is relatively small, below 10%; the adsorption rate of famotidine and ranitidine decreases with the increase of pH value. Conclusions Montmorillonite powder has different adsorption effects on the above drugs. Pay attention to the medication interval when using the drug with large absorption rate.