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目的:观察复发性口腔溃疡患者应用玉屏风颗粒与地塞米松粘贴片联合治疗的临床效果,为该病治疗提供参考。方法:选取新疆维吾尔自治区人民医院2013年6月到2015年6月150例复发性口腔溃疡患者作为研究对象,将其按照随机信封法(含有A、B、C三个分组标签的信封各50个,共150个)分为三组,各50例。A组给予口服玉屏风颗粒治疗,B组给予贴附地塞米松粘贴片治疗,C组给予玉屏风颗粒与地塞米松粘贴片联合治疗,观察三组的临床治疗效果。结果:C组治疗有效率94.0%,显著高于A组的80.0%、B组的78.0%,数据差异有统计学意义(P<0.05;治疗后三组患者平均溃疡期和溃疡个数以及IL-2均较治疗前有明显的改善,组间数据差异有统计学意义(P<0.05。C组溃疡复发率6.0%,显著低于A组的18.0%、B组的20.0%,数据差异有统计学意义(P<0.05)。结论:复发性口腔溃疡患者应用玉屏风颗粒与地塞米松粘贴片联合治疗效果显著,缩短溃疡期和减少溃疡个数,降低复发,临床应用价值广。
Objective: To observe the clinical effect of combined treatment of Yupingfeng granule and dexamethasone adhesive patch in patients with recurrent oral ulcer, and provide reference for the treatment of the disease. Methods: A total of 150 recurrent oral ulcer patients from June 2013 to June 2015 in People’s Hospital of Xinjiang Uygur Autonomous Region were selected as study subjects. According to the random envelope method (including 50 envelopes of A, B and C respectively , A total of 150) divided into three groups, each 50 cases. Group A was treated with oral Yupingfeng granule, group B was treated with dexamethasone adhesive patch, group C was treated with Yupingfeng granule and dexamethasone adhesive patch, and the clinical effect of the three groups was observed. Results: The effective rate of treatment in group C was 94.0%, which was significantly higher than 80.0% in group A and 78.0% in group B, the difference was statistically significant (P <0.05). The mean ulcer and ulcer number, -2 were significantly improved than before treatment, the data between the two groups were statistically significant (P <0.05.C group of ulcer recurrence rate was 6.0%, significantly lower than 18.0% in group A, 20.0% in group B, the data differences are (P0.05) .Conclusion: The treatment of recurrent oral ulcer patients with Yupingfeng particles and dexamethasone adhesive patch combined with significant effect, shorten the ulcer period and reduce the number of ulcers and reduce recurrence, the clinical value.