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作者应用免疫组化方法检测29例胃癌患者原发灶及其淋巴结转移灶等不同组织的α4和β1亚单位整合素在这情况，发现原发灶和淋巴结转移灶中α4、β1亚单位的染色特征发生明显改变。原发灶组和减淋巴结组的表达程度明显强于邻近非肿瘤胃粘膜组；在原发灶组中，α4、β1的表达强度与胃癌生长方式、分化程度、浸润深度、淋巴道和肝脏转移状况、Borrmann分型或TNM分期等临床病理因素密切相关。
The authors used immunohistochemistry to detect α4 and β1 subunit integrins in different tissues such as primary tumors and their lymph node metastases in 29 patients with gastric cancer. In this case, the staining of α4 and β1 subunits in primary tumor and lymph node metastases was detected. The characteristics have changed significantly. The primary tumor group and the reduced lymph node group were significantly stronger than the adjacent non-tumor gastric mucosa group; in the primary tumor group, the expression intensity of α4, β1 was correlated with the growth pattern, differentiation degree, infiltration depth, lymphatic metastasis, and liver metastasis of gastric cancer. Status, Borrmann type, or TNM staging are closely related to clinicopathologic factors.