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目的:了解在四川省凉山州地区队列组建中不同招募途径的静脉吸毒人群高危行为及HIV、HCV和梅毒感染特征情况。方法:在队列组建时调查研究对象的招募方式、社会人口学和高危行为特征,采集血样检测HIV、HCV和梅毒感染情况。结果:在379名招募的静脉吸毒人群中,309人(81.5%)是通过种子推荐来的,70人(18.5%)是从其他途径获得信息来的。种子介绍的与其他方式招募的研究对象在民族构成、近3个月静脉注射吸毒频率、近3个月海洛因混合安定使用频率差异有统计学意义。近3个月毒品使用的其他方式、注射器具共用情况、性行为和血样HIV、HCV和梅毒检测结果上差异无统计学意义(P>0.05)。结论:采用应答驱动抽样方法是招募静脉吸毒人员行之有效的方法,但尚需进一步探讨其对参加者高危行为特征与血清学检测结果的影响。
OBJECTIVE: To investigate the high-risk behavior and HIV, HCV and syphilis infection among intravenous drug users with different recruitment channels in the cohort of Liangshan Prefecture in Sichuan Province. Methods: During the formation of the cohort, the methods of recruitment, social demography and characteristics of high-risk behaviors were investigated. Blood samples were collected to detect the infection of HIV, HCV and syphilis. Out of 379 enrolled intravenous drug users, 309 (81.5%) were recommended by seeds and 70 (18.5%) received information from other sources. The introduction of seeds and other forms of recruitment of subjects in the national composition, the frequency of drug abuse intravenous injection of nearly 3 months, nearly 3 months of heroin mixed with stability of the use of frequency was statistically significant. There was no significant difference between the other three methods of drug use in the past three months, the common situation of injecting equipment, sexual behavior, blood samples, HCV and syphilis (P> 0.05). Conclusion: Response-driven sampling is an effective way to recruit intravenous drug addicts. However, it is necessary to further explore the impact of high-risk behaviors and serological test results on participants.