本文叙述了5种药物(盐酸普鲁卡因、苯乙酸钠、aa′-二巯基己二酸钠、巯基丁二酸钠及硫代硫酸钠)对小白鼠腹腔注射吐酒石急性(注射1次,观察3天)及亚急性(注射14天,观察3天)中毒死亡的影响;并将其中有效解毒药分别和吐酒石混合後腹腔注射小鼠14天以治疗日本血吸虫病,然後停药14天解剖,根据平均每鼠余存虫数比较各药对於吐酒石疗效的影响。结果如下: (一)小白鼠腹腔注射吐酒石急性及亚急性LD_(50)分别为38及35毫克/千克/天。 (二)普鲁卡因、苯乙酸钠、aa′-二巯基己二酸钠及巯基丁二酸钠能使小鼠腹腔注射吐酒石急性及亚急性中毒死亡率明显地减低,而硫代硫酸钠则无效。 (三)普鲁卡因、苯乙酸钠、aa′-二巯基己二酸钠及巯基丁二酸钠4种解毒药并不减低吐酒石之疗效,其中普鲁卡因尚能提高吐酒石治疗日本血吸虫病之疗效。 This article describes the acute toxicity of 5 drugs (procaine hydrochloride, sodium phenylacetate, sodium aa’-dimercaptosuccinate, sodium mercaptosuccinate and sodium thiosulfate) (Observed for 3 days) and subacute (injected for 14 days and observed for 3 days). The effective antidote was mixed with tartrazine respectively and injected intraperitoneally for 14 days to treat schistosomiasis japonica, then stopped The medicine was dissected for 14 days and the effect of each medicine on the tartar effect was compared according to the average number of remaining worms per mouse. The results are as follows: (1) The acute and subacute LD 50 of intraperitoneal injection of tartar in mice were 38 and 35 mg / kg / day, respectively. (B) procaine, sodium phenylacetate, sodium aa-dimercaptosuccinate, and sodium mercaptosuccinate can significantly reduce the mortality rate of acute and subacute poisoning in mice injected intraperitoneally with toadstool, while the thio Sodium sulfate is invalid. (C) procaine, sodium phenylacetate, sodium aa-dimercaptosuccinate and mercaptosuccinate four kinds of antidotes do not reduce the efficacy of spit tartar, of which procaine can still improve spit wine Stone treatment of schistosomiasis japonica efficacy.