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作者从1977年9月到1978年3月,对10例(女性7,男性3例)伴有昏迷的暴发型肝炎用高通透性膜间断地进行血液透析治疗,平均年龄为37.7±21.8岁(4～68岁)。肝炎的病原包括2例中毒性(1例是异烟肼及氟烷,另1例是氯丙嗪),1例乙型肝炎,1例巨细胞病毒性,其余6例为HBsAg阴性的病毒性,其中2例分别怀孕3及7个月。生化检查显示有肝细胞衰竭:SGPT为1,643±1,025u/ml(正常为≤38u/ml),总胆红素为23.1±0.9mg%,奎克氏凝血酶原测定为13±7%;因子Ⅱ为10±5%,因子Ⅴ为22±10%,因子Ⅷ+Ⅹ=7±5%。血液过滤在肝昏迷出现后30±16小时(6～60小时)开始,其中2例为肝昏迷2级,1例为3级,7例为4级。血液过滤平均持续92±102小时(6.5～352小时),总过
From September 1977 to March 1978, 10 patients (7 females and 3 males) with fulminant fulminant hepatitis were treated intermittently with high-permeability membranes for hemodialysis, with an average age of 37.7 ± 21.8 years (4 to 68 years old). Hepatitis pathogens include 2 cases of toxicity (1 case of isoniazid and halothane, another case of chlorpromazine), 1 case of hepatitis B, 1 case of cytomegalovirus, and the remaining 6 cases of HBsAg negative virulence , Of which 2 were pregnant 3 and 7 months respectively. Biochemical tests showed hepatocellular failure: SGPT of 1,643 ± 1,025 u / ml (normal ≤ 38 u / ml), total bilirubin of 23.1 ± 0.9 mg%, Quaker prothrombin as 13 ± 7%; factor Ⅱ is 10 ± 5%, factor Ⅴ 22 ± 10%, factor Ⅷ + Ⅹ = 7 ± 5%. Blood filtration began 30 ± 16 hours (6 to 60 hours) after hepatic coma onset, of which 2 were hepatic coma 2, 1 was grade 3, and 7 was grade 4. The average duration of blood filtration 92 ± 102 hours (6.5 ~ 352 hours), total over