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通过干/湿态分离法制备了壳聚糖 明胶不对称膜,研究了制备过程中壳聚糖与明胶的比例及预烘时间对膜结构与性能的影响,用盐酸环丙沙星作为模型药物进行膜后载药,探讨了载药膜对金黄色葡萄球菌的抑菌性能.实验结果表明:制得的膜具有致密的表层结构和海绵状多孔的内层结构.随着不对称膜中明胶含量增大,表层更加致密,内层孔增多,吸水率增加,载药量增加,药物缓释效果显著;随着预烘时间增加,表层更加致密,吸水率减小,载药量减小,药物缓释效果差.
The chitosan gelatin asymmetric membrane was prepared by dry / wet separation method. The effects of the ratio of chitosan to gelatin and the prebaking time on the membrane structure and properties were studied. Ciprofloxacin hydrochloride was used as a model drug The antibacterial activity of drug-loaded membrane against Staphylococcus aureus was investigated.The experimental results show that the membrane has a dense surface structure and sponge-like porous inner layer structure.With the asymmetric membrane gelatin With the increase of content, the surface layer is more dense, the number of inner pores is increased, the water absorption rate is increased, the drug loading is increased, and the sustained-release effect of the drug is remarkable; with the pre-baking time increasing, the surface layer is denser, the water absorption rate is reduced, Slow release of drugs.