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甲型和乙型流感病毒能引起全世界流行的疾病。除引起死亡外,还导致对医疗服务和设施的需求量增加。在流行期间,高度易感人群,如老年人(一般大于65岁),小于18月龄的婴儿和糖尿病或慢性心、肾、呼吸系统疾病的患者可有很高的死亡率。由于流感疫苗效果有限,从而着重寻找能辅助疫苗的特异性抗病毒的化合物。六十年代初发现金刚烷胺和金刚乙胺是抗病毒的药物。尽管实验室和临床已经证明两者均有抗甲型流感病毒所有亚型(H_1N_1、H_2N_2、H_3N_2)的作用,但至今未被广泛应用。
Influenza A and B viruses cause diseases that are prevalent in the world. In addition to causing fatalities, there is an increased demand for medical services and facilities. During the epidemic, high-risk groups, such as older adults (generally> 65 years old), infants less than 18 months of age and those with diabetes or chronic heart, kidney, and respiratory disorders, may have very high rates of mortality. Due to the limited effectiveness of the flu vaccine, the search for specific antiviral compounds that aid in the vaccine. Amantadine and rimantadine were found to be antiviral drugs in the early 1960s. Although laboratory and clinical have proved that both have anti-influenza A virus subtypes (H_1N_1, H_2N_2, H_3N_2) role, but it has not been widely used.