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目的探讨槐杞黄颗粒辅助治疗儿童支气管哮喘的临床疗效及对患儿免疫功能的影响。方法将100例支气管哮喘患儿随机分为对照组与治疗组各50例,均接受常规西医治疗,治疗组同时辅以槐杞黄颗粒治疗,2次/d,<3岁5.0 g/次,≥3岁10 g/次。两组均治疗3个月。比较两组治疗前后白细胞介素-4(IL-4)、IL-5和γ干扰素(IFN-γ)水平,日间和夜间症状积分,临床疗效及随访3个月的复发率。结果两组治疗后血清IL-4、IL-5水平均明显降低,IFN-γ水平均明显升高,同组治疗前后比较差异有统计学意义(P<0.05);治疗组血清IL-4、IL-5水平明显低于对照组,IFN-γ水平明显高于对照组,组间差异有统计学意义(P<0.05)。两组治疗后日间和夜间症状积分均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗组明显低于对照组,组间比较差异有统计学意义(P<0.05)。治疗组总有效率(96.0%)明显优于对照组(82.0%),差异有统计学意义(P<0.05)。治疗组复发3例(6.0%),对照组复发12例(24.0%),治疗组复发率明显低于对照组,差异有统计学意义(P<0.05)。结论槐杞黄颗粒辅助治疗能有效改善支气管哮喘患儿的免疫功能,增强疗效,减少复发。
Objective To investigate the clinical efficacy of Huai Qi Huang Granules in the treatment of childhood bronchial asthma and its effect on immune function in children. Methods A total of 100 children with bronchial asthma were randomly divided into control group and treatment group, 50 cases in each group. All patients received conventional western medicine. The treatment group was supplemented with Huaiqi Huang granules twice a day, 5.0g / ≥ 3 years old 10 g / time. Both groups were treated for 3 months. The levels of interleukin-4 (IL-4), IL-5 and IFN-γ, daytime and nighttime symptom scores, clinical efficacy and recurrence rate at 3 months follow-up were compared between the two groups before and after treatment. Results The serum levels of IL-4 and IL-5 in both groups were significantly decreased and IFN-γ levels were significantly increased after treatment (P <0.05). The levels of IL-4, IL-5 levels were significantly lower than the control group, IFN-γ levels were significantly higher than the control group, the difference between the groups was statistically significant (P <0.05). After treatment, the scores of symptom at daytime and at night were significantly decreased in both groups, with statistical significance (P <0.05); the treatment group was significantly lower than the control group, the difference was statistically significant (P <0.05 ). The total effective rate (96.0%) in the treatment group was significantly better than that in the control group (82.0%), the difference was statistically significant (P <0.05). The recurrence rate of the treatment group was significantly lower than that of the control group (P <0.05). The recurrence rate of the treatment group was significantly lower than that of the control group (P <0.05). Conclusion Huaiqi Huang granules adjuvant therapy can effectively improve the immune function of children with bronchial asthma, enhance the efficacy and reduce recurrence.