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目的:评价双磷酸盐联合甲氨喋呤治疗绝经后类风湿关节炎患者疗效,分析治疗方法对类风湿关节炎活动度指标的影响。方法:选择2005~2007年我院住院及门诊的活动期类风湿关节炎患者75例,随机双盲分为2组,其中甲氨喋呤组45例,甲氨喋呤+双磷酸盐组30例。检测两组使用药物前后患者疾病活动性指标及血清中类风湿关节炎活动度相关指标,评价甲氨喋呤+双磷酸盐治疗方法的疗效。结果:甲氨喋呤+双磷酸盐治疗组可以提高骨密度,治疗后两组观察指标比较,甲氨喋呤+双磷酸盐组疾病活动度指标改善明显好于单用甲氨喋呤组。结论:双磷酸盐能有效防止骨丢失,帮助类风湿关节炎病情缓解。
OBJECTIVE: To evaluate the efficacy of bisphosphonates combined with methotrexate in the treatment of post-menopausal rheumatoid arthritis patients and to analyze the effect of treatment on rheumatoid arthritis activity index. Methods: Seventy-five patients with active rheumatoid arthritis in our hospital and outpatient department from 2005 to 2007 were randomly divided into two groups: methotrexate group (n = 45), methotrexate + bisphosphonate group example. The indexes of disease activity and the activity of rheumatoid arthritis in serum were measured before and after treatment in both groups to evaluate the efficacy of methotrexate plus bisphosphonate treatment. Results: Methotrexate + bisphosphonate treatment group could increase bone mineral density. After treatment, the improvement of disease activity index of methotrexate + bisphosphonate group was significantly better than that of methotrexate alone group. Conclusion: Bisphosphonates can effectively prevent bone loss and help alleviate rheumatoid arthritis.