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用苯胺、氨基氰、乙酰丙酮三种物质合成了杀菌剂嘧霉胺(C12N3H13).并用溶解量热法在常压、298.15K下,分别测定了苯胺、氨基氰、乙酰丙酮和嘧霉胺在混合溶剂(VDMF:VDMSO=2:1)中的溶解焓:ΔsHmΘ(C6NH7(l),298.15K)=-(12.48±0.16)kJmol-1、ΔsHmΘ(NH2CN(s),298.15K)=-(8.06±0.42)kJmol-1、ΔsHmΘ(CH3COCH2COCH3(l),298.15K)=(1.26±0.03)kJmol-1和ΔsHmΘ[C12N3H13(s),298.15K]=(13.84±0.12)kJmol-1.根据热化学原理求出了298.15K时,合成反应的标准反应热ΔrHmΘ=-(35.65±0.47)kJmol-1,以及嘧霉胺(C12N3H13(s))的标准摩尔生成焓ΔfHmΘ(C12N3H13(s),298.15K)=(198.5±1.5)kJmol-1;用TAMair微量热仪测定了嘧霉胺(C12N3H13(s))在301.15K时对灰葡萄孢菌作用的产热曲线,根据产热曲线求算了在嘧霉胺作用下,灰葡萄孢菌生长代谢的最大发热功率Pmax、最大产热功率的时间tmax、速率常数k和抑制率I等热动力学参数.结果表明:嘧霉胺在低浓度下对灰葡萄孢菌有刺激作用,高浓度下为抑制作用,即嘧霉胺对微生物的生长具有双向生物效应,也称为Hormsis效应.
The antibacterial agent pyrimethanil (C12N3H13) was synthesized by using aniline, cyanamide and acetylacetone, and the aniline, cyanamide, acetylacetone and pyrimethanil were determined at 298.15 K Dissolution enthalpy in mixed solvent (VDMF: VDMSO = 2: 1): ΔsHmθ (C6NH7 (1), 298.15K) = - (12.48 ± 0.16) kJmol-1, ΔsHmΘ (NH2CN (s), 298.15K) = - ( 8.06 ± 0.42) kJmol-1, ΔsHmΘ (CH3COCH2COCH3 (l), 298.15K) = (1.26 ± 0.03) kJmol- 1 and ΔsHmΘ [C12N3H13 (s), 298.15K] = (13.84 ± 0.12) kJmol- The standard reaction heat ΔrHmΘ = - (35.65 ± 0.47) kJ mol-1 and the standard molar enthalpy of formation ΔfHmθ (C12N3H13 (s), 298.15 K) = (198.5 ± 1.5) kJ mol-1. The thermokinetic curve of pyrimethanil (C12N3H13 (s)) on B. cinerea at 301.15K was determined by TAMair calorimeter. Under the action of pyrimethanil, the maximal heating power Pmax, the maximal heating power producing time tmax, the rate constant k and the inhibition rate I of the strain Botrytis cinerea were studied.The results showed that pyrimethanil at low concentration Botrytis cinerea stimulate Use, high concentrations of inhibition, i.e., with two-way pyrimethanil biological effects on microbial growth, also known as Hormsis effect.