论文部分内容阅读
目的探讨microRNA-24(miR-24)表达与急性脑梗死进展的关联性。方法选取急性脑梗死患者151例,根据有无脑梗死进展(PCI)分为进展组64例和对照组87例,另选取健康体检者30例为正常组。收集3组的人口学特征(性别、年龄)和常见脑血管病危险因素(高血压病、高脂血症、糖尿病、冠心病、心房纤颤史等),比较3组的miR-24表达、高同型半胱氨酸(Hhcy)、入院后血压降低、颅内动脉狭窄、空腹血糖和纤维蛋白原水平等情况。结果进展组与对照组比较,患者的性别、年龄及高血压病、冠心病、糖尿病、脑卒中病史、高脂血症、心房颤动发生率,差异无统计学意义(P>0.05);进展组空腹血糖、Hhcy、入院后血压降低及颅内动脉狭窄率高于对照组,miR-24表达水平低于对照组及正常组,差异有统计学意义(P<0.05)。多因素Logistic回归分析表明,miR-24低表达、Hhcy、入院后血压降低、空腹血糖升高是急性脑梗死进展的独立危险因素(P<0.05)。结论 miR-24能抑制神经细胞缺血缺氧条件下的凋亡,急性脑梗死miR-24低表达患者的病情进展风险大。
Objective To investigate the relationship between the expression of microRNA-24 (miR-24) and the progression of acute cerebral infarction. Methods 151 patients with acute cerebral infarction were divided into 64 cases of progressive group and 87 cases of control group according to the progress of cerebral infarction (PCI). Another 30 healthy subjects were selected as normal group. The demographic characteristics (gender, age) and common risk factors of cerebrovascular disease (hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease and atrial fibrillation history) were compared among the three groups. The expression of miR-24, Homocysteine (Hhcy), lower blood pressure after admission, intracranial arterial stenosis, fasting blood glucose and fibrinogen levels and so on. Results There were no significant differences in the incidence of hypertension, coronary heart disease, diabetes mellitus, stroke, hyperlipidemia and atrial fibrillation between the progress group and the control group (P> 0.05). The progression group Fasting blood glucose, Hhcy, blood pressure after admission and intracranial artery stenosis rate were higher than those in control group, and miR-24 expression level was lower than that in control group and normal group (P <0.05). Multivariate Logistic regression analysis showed that low expression of miR-24, Hhcy, post-admission blood pressure and fasting blood glucose were independent risk factors for the progression of acute cerebral infarction (P <0.05). Conclusion miR-24 can inhibit the apoptosis of neurons in the condition of hypoxia and hypoxia. The patients with low expression of miR-24 in acute cerebral infarction are at high risk.