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目的 探讨肟类药物氯解磷定(PAM Cl)治疗急性敌敌畏(DDV)中毒的疗效和作用机制。方法 比较急性DDV灌胃染毒大、小鼠用PAM Cl治疗与未治疗的中毒表现、存活率及大鼠全血胆碱酯酶(ChE)活力的变化;观察PAM Cl治疗急性DDV中毒患者的疗效和对其被抑制的全血ChE的重活化作用。结果 (1)急性DDV染毒大、小鼠PAM Cl治疗组与未治疗组相比,中毒表现减轻、出现时间延迟,存活率明显提高;(2 )急性DDV染毒大鼠PAM Cl治疗组不同时点全血ChE活力普遍高于未治疗组,差异有统计学意义(P <0 .0 5 ) ;(3)急性DDV中毒患者PAM Cl治疗后肌束震颤明显减轻并消失,受抑制的ChE活力逐渐恢复。结论 PAM Cl对急性DDV中毒有治疗作用,该作用是通过ChE重活化效应来实现的
Objective To investigate the efficacy and mechanism of oxime drug Clcl in the treatment of acute dichlorvos (DDV) poisoning. Methods The acute and chronic DDV-infected rats were treated with PAM Cl, and the untreated poisoned mice were sacrificed and the survival rate and the activity of ChE in rats were compared. The effects of PAM Cl on acute DDV poisoning were observed Curative effect and reactivation of ChE which is inhibited by whole blood. Results (1) Compared with the untreated group, the mice in the acute DDV-treated group had significantly reduced toxin poisoning and delayed time, and the survival rate was significantly increased. (2) At the same time point ChE activity of whole blood was generally higher than that of untreated group, the difference was statistically significant (P <0.05); (3) Acute DDV poisoning patients with PAM Cl significantly reduced and disappeared after the treatment of muscle tremor, suppressed ChE Vitality gradually restored. Conclusions PAM Cl has a therapeutic effect on acute DDV poisoning through the ChE reactivation effect