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目的研究原发性高血压患者血清中抗血管紧张素Ⅱ1型受体自身抗体(AT1-AAs)与血尿酸和肌酐的关系。方法收集原发性高血压患者血清样本344份,以酶联免疫吸附试验法检测AT1-AAs水平,以尿素酶法检测尿酸浓度,酶法检测肌酐、尿素氮浓度;按抗体稀释滴度分为抗体阴性组、1?40、1?80和1?160及以上组,比较各组患者血清肌酐及尿酸水平的差异。结果随抗体滴度升高,血肌酐水平逐渐上升,而血尿酸则逐渐下降[肌酐:(83.2±56.0),(85.3±48.9),(103.2±88.0),(144.7±136.1)μmol/L;尿酸:(344.2±118.6),(332.1±126.2),(332.2±127.6),(235.0±106.3)μmol/L;均P<0.05]。多分类有序变量logistic回归分析表明,影响AT1-AAs的因素为年龄、血肌酐和尿酸(OR值分别为1.031,2.374,0.881;均P<0.05)。结论原发性高血压患者血清中AT-AAs与血肌酐水平呈正相关;而与血尿酸水平呈负相关。
Objective To investigate the relationship between serum autoantibodies against angiotensin Ⅱ 1 (AT1-AAs) and serum uric acid and creatinine in patients with essential hypertension. Methods A total of 344 serum samples from patients with essential hypertension were collected to detect the level of AT1-AAs by enzyme-linked immunosorbent assay (ELISA), the concentration of uric acid (UA), the creatinine and urea nitrogen Antibody negative group, 1? 40,1? 80 and 1? 160 and above groups, serum creatinine and uric acid levels were compared between groups. Results Serum creatinine increased with the increase of antibody titers, while serum uric acid gradually decreased [creatinine (83.2 ± 56.0), (85.3 ± 48.9), (103.2 ± 88.0) and (144.7 ± 136.1) μmol / L, Uric acid: (344.2 ± 118.6), (332.1 ± 126.2), (332.2 ± 127.6), (235.0 ± 106.3) μmol / L, all P <0.05]. Logistic regression analysis showed that the factors influencing AT1-AAs were age, serum creatinine and uric acid (OR = 1.031, 2.374, 0.881, respectively; all P <0.05). Conclusion Serum levels of AT-AAs in patients with essential hypertension are positively correlated with serum creatinine levels, but negatively correlated with serum uric acid levels.