环孢素(cyclosporine,CsA)是一种广泛用于治疗器官移植及自身免疫性疾病的免疫抑制药,该药安全范围窄,个体差异大,需要监测其血浓度。CsA主要不良反应之一为牙龈增生,国外文献报道肾移植受者牙龈增生的发生率为21%～35%,临床常用甲硝唑治疗。本文探讨甲硝唑对肾移植受者CsA血浓度的影响,为临床安全、有效使用提供依据。 Cyclosporine (CsA) is an immunosuppressive drug widely used in the treatment of organ transplantation and autoimmune diseases. It has a narrow safety range and individual differences and requires monitoring its blood concentration. One of the main adverse reactions of CsA is gingival hyperplasia. The incidence of gingival hyperplasia in renal transplant recipients has been reported in foreign countries from 21% to 35%. Metronidazole is commonly used clinically. This article discusses the impact of metronidazole on CsA blood concentration in renal transplant recipients, providing a basis for clinical safe and effective use.