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目的探讨幽门螺杆菌(Hp)清除治疗对反流性食管炎(RE)疗效的影响。方法将已确诊的58例Hp阳性的RE病人随机分为两组。其中观察组30例,对照组28例。两组病人均给予口服质子泵抑制剂和对症治疗,观察组在治疗的同时加用克拉霉素和阿莫西林作Hp抗菌治疗,对照组则不作Hp抗菌治疗。总疗程均为4周。疗程结束后比较两组病人的症状、胃镜下黏膜损害的改善程度。结果两组病人的症状改善程度差异无显著性,胃镜下黏膜损害改善程度差异亦无显著性。结论清除Hp与否对于RE病人,无论是临床症状的控制,还是黏膜损害性病变的改善并不产生显著影响。
Objective To investigate the effect of Helicobacter pylori (Hp) clearance on the efficacy of reflux esophagitis (RE). Methods 58 confirmed Hp positive RE patients were randomly divided into two groups. The observation group of 30 cases, control group of 28 cases. Two groups of patients were given oral proton pump inhibitors and symptomatic treatment, observation group were treated with clarithromycin and amoxicillin for Hp antibacterial treatment, the control group was not treated with anti-Hp. The total course of treatment is 4 weeks. After the end of treatment, the symptoms of the two groups of patients were compared, and the degree of improvement of mucosal lesions under endoscopy was compared. Results There was no significant difference in the improvement of symptoms between the two groups. There was no significant difference in the improvement of mucosal damage under gastroscope. Conclusion Clearing Hp or not in patients with RE, whether it is the control of clinical symptoms, or mucosal lesion improvement does not have a significant impact.