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目的 探讨肺鳞癌中ＨＰＶ与Ｐ５３ 蛋白的表达状况、两者的关系及其在肺鳞癌发生机制中可能的作用。方法 使用免疫组化ＬＳＡＢ法检测３７ 例肺鳞组织中ＨＰＶ 及Ｐ５３ 蛋白的表达。结果 ３７ 例肺鳞癌其中９例（２４－３％）ＨＰＶ阳性，２３ 例（６２－２ ％）Ｐ５３ 蛋白阳性。肺鳞癌的分化程度与ＨＰＶ和Ｐ５３ 的阳性表达无关。结论 ＨＰＶ感染可能与部分肺鳞癌的发生有关。Ｐ５３ 基因突变或野生型Ｐ５３ 蛋白与ＨＰＶ合成的Ｅ６ 蛋白结合可能会导致肺鳞癌的发生。
Objective To investigate the expression status of HPV and P53 protein in lung squamous cell carcinoma and their relationship with the pathogenesis of lung squamous cell carcinoma. Methods The expression of HPV and P53 protein in 37 cases of lung squamous cell tissue was detected by immunohistochemical LSAB method. Results Of the 37 lung squamous cell carcinomas, 9 (24-3%) were positive for HPV and 23 (62-2%) were positive for P53. The degree of differentiation of lung squamous cell carcinoma is not related to the positive expression of HPV and P53. Conclusion HPV infection may be related to the occurrence of some lung squamous cell carcinomas. The mutation of P53 gene or wild-type P53 protein combined with HPV synthesized E6 protein may lead to the occurrence of lung squamous cell carcinoma.