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阿司匹林是重要的非甾体抗炎药,通过抑制全身的环氧合酶发挥解热、镇痛、抗炎和抗血小板的作用,在心脑血管疾病及风湿免疫性疾病中被广泛使用.新生血管本是机体的一种自我修复,但同时在肿瘤及眼科各种疾病中也扮演着破坏者的角色.阿司匹林对病理性新生血管的产生到底发挥着何种作用,目前尚处于争论阶段:一方面,阿司匹林对于新生血管产生作用最强的作用因子血管内皮生长因子(VEGF)有一定的抑制作用;另一方面,阿司匹林又因抑制抗新生血管最强的因子,即内皮抑素生成,从而促进VEGF的生成.再者,阿司匹林对于眼部的血-视网膜屏障也有破坏作用,这在某种程度上也能造成眼底新生血管的生成.同时,我们分析了出现眼部新生血管的疾病中阿司匹林的作用.今后的研究中,阿司匹林在眼科领域与脉络膜新生血管生成中的关系急需得到进一步阐明,应综合衡量阿司匹林在新生血管防治中的利弊.“,”Aspirin is one of the most important non-steroidal anti-inflammatory drugs,could inhibit cyclooxygenase.It has the antipyretic-analgesic,anti-inflammatory and anti-platelet effects,and has been widely used in preventing heart cerebrovascular disease and rheumatic autoimmune disease.Neovascularization is a self-healing mechanism.However,it also plays the role of the destroyer in cancer and eye diseases at the same time.The pathology of aspirin in the generation of neovascularization,is still in the stage of a fierce debate.On one hand,aspirin has a certain inhibitory effect to the vascular endothelial growth factor (VEGF),which is the strongest factor in neovascularization.On the other hand,aspirin also has the strongest inhibitory effect to endostatin,which is a kind of anti-neovascularization factor.That may lead to the producing of VEGF.Moreover,aspirin may destroy the blood retinal barrier (BRB),which can also cause the formation of retinal neovascularization in a way.Meanwhile,we analyzed the role of aspirin in diseases which can form the neovascular.In the future study,the relationship between aspirin and neovascularization of eye will be further studied.We must measure the pros and cons in the prevention and control of neovascularization when using aspirin.