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目的 :探讨三七总甙片和洛汀新治疗早期糖尿病肾病 (DN )的疗效和机理。方法 :48例早期 DN患者随机分为三七总甙片组 (2 4例 ,三七总甙片 3片 /次 ,每日 3次 )和洛汀新组 (2 4例 ,洛汀新 10 mg,每日 1次 ) ,采用对比研究方法 ,观察治疗早期 DN的疗效和相关指标变化。结果 :两组患者的尿蛋白 (AL B) ,β2 -微球蛋白 (β2 -MG)均显著下降 (P<0 .0 1)。且洛汀新组高于三七总甙片组 (P<0 .0 5 )。两组患者的肌酐清除率 (CCr均明显下降 (P<0 .0 1)。结论 :三七总甙片和洛汀新治疗早期 DN均具有降低尿白蛋白和改善肾功能功效。
Objective: To investigate the effect and mechanism of Panax Notoginseng Tablet and Lotensin on early diabetic nephropathy (DN). Methods: Forty-eight patients with early DN were randomly divided into Panax notoginseng group (24 cases, Panax notoginseng group 3 tablets / time, three times a day) and Lotensin group (24 cases, Lotensin 10 mg, once a day), the use of comparative study methods to observe the early treatment of DN efficacy and changes in relevant indicators. Results: Urinary protein (AL B) and β2 - microglobulin (β2 - MG) in both groups were significantly decreased (P <0.01). And Lotensin group was higher than Panax notoginseng group (P <0.05). Creatinine clearance (CCr) was significantly decreased in both groups (P <0.01) .Conclusion: Panax notoginseng glycosides tablets and Lotensin treatment of early DN have the effect of reducing urinary albumin and improving renal function.