急性肾功能衰竭（ＡＲＦ）的发病机制尚不清楚。本实验将大鼠预先用一氧化氮（ＮＯ）的底物Ｌ－精氨酸（Ｌ－Ａｒｇ）处理后，用甘油诱导ＡＲＦ，观察Ｌ－Ａｒｇ对ＡＲＦ的保护作用并探讨ＮＯ产生异常在ＡＲＦ发生、发展中的意义。１　材料和方法１．１　动物　雄性Ｗｉｓｔａ The pathogenesis of acute renal failure (ARF) is not clear. In this experiment, rats were pretreated with L-arginine (L-Arg), a substrate of nitric oxide (NO), and ARF was induced with glycerol to observe the protective effect of L-Arg on ARF and to explore whether NO production was abnormal in ARF What happened, the meaning of development. 1 Materials and Methods 1.1 Animal Male Wista