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目的了解吉林地区妇女正常妊娠、妊娠糖耐量受损、妊娠糖尿病的糖耐量水平。方法 4家医院联合前瞻性对1987名孕妇在孕24～32周间先行50g糖筛查试验,不管其值高低均于3d后行口服葡萄糖耐量试验(OGTT)。结果 OGTT按美国国家糖尿病资料组(NDDG)标准判断正常组1153名,取其4次血糖值的第97.5百分位数为5.36、9.62、6.58和6.82mmol/L。OGTT中1项异常或2h血糖值在6.67～9.11mmol/L之间为GIGT组751名,第97.5百分位数血糖值为6.11、11.90、9.59、和8.02mmol/L。GDM组83例,其中72例根据OGTT4项值中≥2项异常确诊,其血糖值为8.02、16.88、14.42和11.70mmol/L。结论吉林地区正常孕妇OGTT第97.5百分位数的血糖值略低于国内外报道。目前应用的NDDG诊断标准是否过高导致假阴性,有待进一步调查研究。
Objective To understand the normal pregnant women in Jilin area, gestational impaired glucose tolerance, gestational diabetes mellitus and glucose tolerance levels. METHODS: Forty-seven hospitals were prospectively performed the screening test of 509g of sugar in 1987 pregnant women between 24 and 32 weeks of gestation. Oral glucose tolerance test (OGTT) was performed after 3d in both hospitals. Results According to the National Diabetes Data Group (NDDG) criteria, OGTT judged 1153 normal subjects. The 97.5th percentile of four blood glucose values was 5.36, 9.62, 6.58 and 6.82 mmol / L respectively. One abnormality or 2h blood glucose level in OGTT was 751 in the GIGT group and the 97.5th percentile blood glucose value was 6.11, 11.90, 9.59 and 8.02mmol / L in the range of 6.67 ~ 9.11mmol / L. 83 cases of GDM group, of which 72 cases were diagnosed according to OGTT4 items ≥2 abnormalities, the blood glucose values were 8.02,16.88,14.42 and 11.70mmol / L. Conclusion The blood glucose level of the 97.5th percentile of OGTT in normal pregnant women in Jilin area is slightly lower than that reported in China and abroad. Currently used NDDG diagnostic criteria is too high lead to false negatives, pending further investigation.