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血浆血管紧张素Ⅱ(PATⅡ)经 Sep-pakC~(18)柱和高压液相层析(HPLC)分离,放射免疫(RIA)测定。并通过8例原发性高血压病人进行了巯甲丙脯酸抑制 PATⅡ生成的研究。结果显示,口服25mg 巯甲丙脯酸后10分钟,PATⅡ水平即有显著下降(P<0.01),60分钟时达最低水平(P<0.02)。平均动脉压(MAP)亦同时达到最低水平(P<0.02)。下降率为34%。60分钟后,APTⅡ,MAP 均逐渐回升。血浆肾素活性(PRA)在用药后30分钟内未见显著性变化。PRA水平反馈增高,但与 MAP 变化无同时达到峰值的相应关系。
Plasma angiotensin Ⅱ (PATⅡ) was separated by Sep-PakC 18 column and high pressure liquid chromatography (HPLC) and radioimmunoassay (RIA) was performed. A study on the inhibition of PAT II production by captopril was conducted in 8 patients with essential hypertension. The results showed that PATⅡ level decreased significantly (P <0.01) and reached the lowest level at 60 minutes (P <0.02) 10 minutes after oral administration of 25 mg captopril. Mean arterial pressure (MAP) also reached the lowest level at the same time (P <0.02). The rate of decline is 34%. After 60 minutes, APTⅡ, MAP gradually rose. Plasma renin activity (PRA) showed no significant change within 30 minutes after treatment. PRA increased the level of feedback, but did not change at the same MAP with the corresponding peak.