阿托伐他汀是广泛用于临床的降血脂药物,是心血管疾病一级和二级预防最有效的治疗手段之一。尽管大多数人能很好地耐受这一药物,但极少数人也会出现严重的副作用;而且,在人群中其降脂疗效存在明显的个体差异。这些差异与基因的多态性有关。本文综述了阿托伐他汀药物基因组学研究进展,为阿托伐他汀的个体化使用提供参考依据。 Atorvastatin is widely used in clinical hypolipidemic drugs, and is one of the most effective treatments for primary and secondary prevention of cardiovascular diseases. Although most people tolerate the drug well, very few people experience severe side effects; and there are significant individual differences in their lipid-lowering efficacy in the population. These differences are related to the genetic polymorphism. This review summarizes the progress of atorvastatin pharmacogenomics and provides a reference for the individualized use of atorvastatin.