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用放射免疫分析法测定了５６例原发性高血压患者血浆内皮素（ＥＴ）水平，并同时测定了血管紧张素Ⅱ（ＡⅡ）和心钠素（ＡＮＦ）的血浆水平，以探讨ＥＴ、ＡⅡ和ＡＮＦ在原发性高血压发病中的作用。结果，原发性高血压患者血浆ＥＴ、ＡⅡ及ＡＮＦ水平比对照组明显升高。而且，随着高血压病病情的发展，ＥＴ水平逐渐升高；ＥＴ水平的增高与ＡⅡ和ＡＮＦ水平增高呈正相关。用转换酶抑制剂依那普利治疗，三者水平均明显下降。推断高血压病的发生和进展与血浆ＥＴ水平增高有关，并通过ＡⅡ和ＡＮＦ进一步影响高血压病病情的进展。使用转换酶抑制剂引起的血压下降可能与血浆ＥＴ含量减少及ＡⅡ和ＡＮＦ含量同时减少有关。
The levels of plasma endothelin (ET) were measured in 56 patients with essential hypertension by radioimmunoassay. The plasma levels of angiotensin Ⅱ (AⅡ) and atrial natriuretic peptide (ANF) were also measured to explore the relationship between ET, AⅡ And ANF in the pathogenesis of essential hypertension. Results, plasma ET, A Ⅱ and ANF levels in patients with essential hypertension were significantly higher than the control group. Moreover, with the development of hypertension, the level of ET gradually increased; the increase of ET level was positively correlated with the increase of AⅡ and ANF levels. With conversion enzyme inhibitor enalapril treatment, the three levels were significantly decreased. It is concluded that the occurrence and progression of hypertension are related to the increase of plasma ET level and further affect the progression of hypertension by AⅡ and ANF. The decrease of blood pressure caused by converting enzyme inhibitors may be related to the decrease of plasma ET content and the simultaneous decrease of AⅡ and ANF contents.