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为提高壳聚糖支架材料的孔隙率及矿化程度,通过磷酸化表面改性和仿生矿化制备了磷酸化(PCSW)和生物矿化(BMCW)木垛型壳聚糖多孔支架。FTIR结果显示,壳聚糖分子中有磷酸根的引入。XRD结果表明,矿化24h后支架上形成结晶度较高的磷酸钙盐晶体,矿化48h后结晶度明显增加并形成单纯的羟基磷灰石(HA)结晶。SEM观察发现,在支架的内外表面均致密地沉积了HA晶体层。压缩强度测试结果表明,复合支架BMCW矿化48h的压缩强度为(0.54±0.005)MPa,压缩模量为(5.47±0.65)MPa,BMCW可用作非承重骨组织修复材料。
In order to improve the porosity and mineralization of chitosan scaffolds, phosphorated (SiCW) and biomineralized (BMCW) porous chitosan porous scaffolds were prepared by phosphorylated surface modification and biomimetic mineralization. FTIR results show the incorporation of phosphate into chitosan molecules. The results of XRD showed that calcium phosphate crystals with high degree of crystallinity formed on the scaffolds after mineralization for 24 hours. After 48 hours of mineralization, the crystallinity increased significantly and pure hydroxyapatite (HA) crystals formed. SEM observation showed that the HA crystal layer was densely deposited on the inner and outer surfaces of the stent. Compressive strength test results show that the compressive strength of BMCW after 48h mineralization is (0.54 ± 0.005) MPa and the compressive modulus is (5.47 ± 0.65) MPa. BMCW can be used as a non-load-bearing bone tissue repair material.