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氧化应激(OS)是指机体受到多种因素刺激后,体内活性氧簇(ROS)产生过多,抗氧化能力下降,打破了机体正常氧化还原动态平衡,造成生物大分子如蛋白质、脂质和核酸等的氧化损伤,干扰正常生命活动而形成的一种严重的应激状态。本文从氧化应激对肺脏、肝脏及心血管系统等脏器的损害表述氧化应激与器官损害之间互相作用,互相影响的关系,此外简述了吸入氧浓度对氧化应激的影响及抗氧化治疗的现状。
Oxidative stress (OS) refers to the body after being stimulated by a variety of factors, the body produces excessive reactive oxygen species (ROS), decreased antioxidant capacity, breaking the body’s normal redox dynamic equilibrium, resulting in biological macromolecules such as protein, lipid And nucleic acid oxidation damage, interference with normal life activities and the formation of a serious stress state. In this paper, the oxidative stress on the lungs, liver and cardiovascular system and other organs of the damage described the relationship between oxidative stress and organ damage, mutual influence, in addition to briefly describe the effects of inhaled oxygen concentration on oxidative stress and resistance The status of oxidative therapy.