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引言１９８８年，Ｓｔｅｅｇ等［１］首先从具有不同转移能力的小鼠黑色素瘤Ｋ－１７３５细胞系分离并鉴定了ｎｍ２３基因，证实了ｎｍ２３基因与恶性肿瘤转移抑制有关．它的编码产物为二磷酸激酶（ｎｕｃｌｅｏｓｉｄｅｄｉｐｈｏｓｐｈａｔｅｋｉｎａｓｅ，ＮＤＰＫ），...
Introduction In 1988, Steeg et al.[1] first isolated and identified the nm23 gene from mouse melanoma K-1735 cell lines with different metastatic capacities, confirming that nm23 gene is involved in metastasis inhibition of malignant tumors. Its coding product is nucleoside diphosphate kinase (NDPK),...