目的　观察持续肾脏替代治疗 (CRRT)在ICU抢救危重病人的治疗效果与存活率的关系。方法　治疗 94例急、慢性肾衰及多脏器衰竭 (MOF)的病人 ,其中应用持续性动脉—静脉血液滤过 (CAVH) 2 8例和持续性静脉—静脉血液滤过(CVVH) ) 6 6例。结果　①将患者年龄分为 4组 ,即 <30岁、30～ 5 0岁、5 0～ 70岁、>70岁年龄组 ,随年龄增高存活率逐渐下降 ,具有显著性差异P <0 0 0 1。② 1个脏器衰竭有 2 7例 ,存活率 6 7% ;2个脏器衰竭 ,有 33例 ,存活率 10 % ;3个脏器衰竭有 34例 ,存活率 9% ;三者具有显著性差异 ,P <0 0 0 1。③对CAVH组 2 8例及CVVH组 6 6例的存活率进行统计分析 ,两组无显著性差异。④患者经过平均连续 7d的血滤 ,治疗前后血BUN及血Cr均有明显的下降 ,具有显著性差异 ,P <0 0 1;而存活组与死亡组溶质的清除率无显著性差异 ,P >0 0 5。结论　CRRT是抢救危重病人的有效手段之一 ,不受年龄的限制 ,患者耐受性较好 ,能有效地清除小分子物质 ,病人的存活率与年龄和病人的器官衰竭数目有关 ,年龄越大 ,脏器衰竭数目越多 ,其死亡率越高。 Objective To observe the relationship between the therapeutic effect and survival rate of continuous renal replacement therapy (CRRT) in critically ill patients undergoing ICU salvage. Methods Ninety-four patients with acute and chronic renal failure and multiple organ failure (MOF) were treated with continuous arteriovenous hemofiltration (CAVH) 28 and continuous venovenous hemofiltration (CVVH) 6 6 cases. Results ① The patients were divided into 4 groups, namely, <30 years old, 30 ~ 50 years old, 50-70 years old,> 70 years old group. The survival rate decreased with age, with significant difference P <0 0 0 1. (2) There were 27 cases of one organ failure, the survival rate was 67%; two organ failure, 33 cases, the survival rate of 10%; 3 organ failure in 34 cases, the survival rate of 9%; three were significant Sex differences, P <0 0 0 1. ③ The statistical analysis was performed on the survival rate of 66 cases in CAVH group and 66 cases in CVVH group, with no significant difference between the two groups. ④After an average of 7 days of continuous hemofiltration, the levels of BUN and blood Cr decreased significantly after treatment, with significant difference (P <0.01). There was no significant difference in solute clearance between survivors and deaths, P > 0 0 5. Conclusion CRRT is one of the effective measures to rescue critically ill patients. Without limitation of age, patients are well tolerated and can effectively remove small molecule substances. The survival rate of patients is related to the age and the number of patients with organ failure. The older the patients, , The more the number of organ failure, the higher the mortality rate.