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目的:研究中药组方作为血管栓塞剂的有效性、安全性及相关特性,以期获得一种理想的肿瘤血管栓塞剂。方法:根据药典提供的数味具有抗癌和促凝作用的中草药将其制备成栓塞剂。对其进行一系列有关特性的研究和鉴定,并应用其进行8头健康猪的肝动脉栓塞实验。结果:中药组方栓塞剂为一种混县剂,有一定粘滞性,不透X线,易经各种介入用导管注射;该栓塞剂具有良好的血液相容性和组织相容性,无致热原性及毒性作用;栓塞部位主要是末梢小动脉,栓塞牢靠,维持时间可达5周,不易形成侧枝循环;经光镜和电镜观察其对正常肝组织损伤轻微,仅出现栓塞部位的肝细胞水变性和臆浆灶性坏死。结论:中药组方检塞剂具有良好的血管栓塞作用,使用方便、安全,是一种较理想的末梢型血管栓塞剂。
OBJECTIVE: To study the efficacy, safety and related characteristics of traditional Chinese medicine as a vascular embolizing agent in order to obtain an ideal tumor vascular embolizing agent. Methods: According to the pharmacopoeia provided several Chinese herbs with anti-cancer and pro-coagulant effects were prepared into embolic agents. A series of related characteristics were studied and identified, and applied to hepatic artery embolization experiments in 8 healthy pigs. RESULTS: The Chinese herbal formula embolic agent was a mixed agent with certain viscosity, not radiopaque, and was easily injected by various interventional catheters; the embolization agent had good blood compatibility and tissue compatibility. No pyrogenic and toxic effects; the embolization site is mainly peripheral arterioles; the embolization is reliable; the maintenance time is up to 5 weeks; collateral circulation is not easy to occur; the damage to normal liver tissue is slight and only embolic sites are observed by light and electron microscopy. Hepatic water degeneration and necrosis of palpebral fossa. Conclusion: The traditional Chinese medicine prescription seizure agent has good vascular embolism and is easy to use and safe. It is an ideal peripheral vascular embolization agent.