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目的探讨食管癌根治术后影响临床预后的因素。方法回顾性分析我院1987年至2003年614例食管癌根治术后患者资料,采用Kaplan-Meier法计算生存率,Log-Rank检验比较生存差别和Cox多因素回归对本组病例的预后因素进行分析。结果总的3年和5年生存率分别为34.1%,25.2%;年龄、病变长度、病理分期和术后辅助放疗是食管癌生存率影响因素(P均<0.05);性别、肿瘤分化程度对食管癌生存率影响差异无统计学意义(P>0.05)。结论高龄患者应充分考虑生理年龄,慎重选择手术治疗;早期诊断、早期手术治疗和术后规范辅助放疗,可提高食管癌患者生存率。
Objective To investigate the factors influencing clinical prognosis after radical operation of esophageal cancer. Methods The data of 614 patients with esophageal cancer after radical operation in our hospital from 1987 to 2003 were retrospectively analyzed. The survival rate was calculated by Kaplan-Meier method. The prognostic factors in this group were analyzed by Log-Rank test, survival difference and Cox multivariate regression analysis . Results The overall 3-year and 5-year survival rates were 34.1% and 25.2% respectively. Age, length of lesion, pathological staging and postoperative adjuvant radiotherapy were the influencing factors for the survival rate of esophageal cancer (all P <0.05) There was no significant difference in the survival rate of esophageal cancer (P> 0.05). Conclusion Elderly patients should fully consider the physiological age, careful choice of surgical treatment; early diagnosis, early surgical treatment and postoperative standard adjuvant radiotherapy, can improve the survival rate of patients with esophageal cancer.