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作者应用ＡＢＣ免疫组化法研究４０例胆囊癌和４２例胆管癌组织中增殖细胞核抗原（ＰＣＮＡ）表达及其意义。高分化和组织学分级Ⅰ级的胆系癌ＰＣＮＡ阳性细胞率评分均数明显低于低分化或未分化和组织学分级Ⅲ级的胆系癌；转移组胆囊癌和胆管癌ＰＣＮＡ阳性细胞率评分均数明显高于未转移组病例。结果提示ＰＣＮＡ阳性细胞率高的胆囊癌和胆管癌预后不良，ＰＣＮＡ可能是反映胆囊癌和胆管癌生物学行为和预后的重要指标。
The authors applied ABC immunohistochemistry to study the expression of proliferating cell nuclear antigen (PCNA) in 40 cases of gallbladder carcinoma and 42 cases of cholangiocarcinoma. The PCNA positive cell rate scores of well-differentiated and histologically graded grade I gallbladder carcinomas were significantly lower than those of poorly differentiated or undifferentiated graded grade III gallbladder carcinomas; the rate of PCNA positive cells in gallbladder carcinoma and cholangiocarcinomas in metastatic group The mean number was significantly higher than that of the non-metastatic group. The results suggest that the prognosis of gallbladder carcinoma and cholangiocarcinoma with high PCNA positive cell rate is poor, and PCNA may be an important indicator reflecting the biological behavior and prognosis of gallbladder carcinoma and cholangiocarcinoma.