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岗梅根为广东凉茶的常用组方药材,三萜皂苷类化合物为其主要和特征性成分。该研究采用硅胶,ODS,Sephadex LH-20,Pre-HPLC等色谱分离技术从岗梅根75%乙醇提取物中分离得到11个三萜皂苷类化合物,经多种波谱技术和化学方法鉴定了它们的结构,分别为3-O-(3-O-sulfo)-β-D-glucopyranosiduronic acid 3β-hydroxy-13(18)-oleanen-28-oic acid 28-O-β-D-glucopyranosyl ester(1)、rotundinoside A(2)、oblonganoside M(3)、3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl 3β,19α-dihydroxy-20α-urs-12-en-28-oic acid 28-O-β-D-glucopyranosyl ester(4)、毛冬青皂苷B2(5)、ilexside II(6)、rotundinoside B(7)、ilekudinoside B(8)、ilexpublesnin E(9)、ilekudinoside D(10)和ilexpernoside D(11)。其中,化合物1为1个新的δ-齐墩果酸型三萜皂苷,化合物2~11为首次从该植物中分离得到。
Gang Meigang is commonly used in Guangdong herbal medicine group ingredients, triterpenoid saponins as its main and characteristic components. In this study, 11 triterpenoid saponins were isolated from 75% ethanol extract of Meh Mee by chromatography on silica gel, ODS, Sephadex LH-20 and Pre-HPLC, and identified by various spectroscopic techniques and chemical methods (3-O-sulfo) -β-D-glucopyranosiduronic acid 3β-hydroxy-13 (18) -oleanen-28-oic acid 28-O-β-D-glucopyranosyl ester ), Rotundinoside A (2), oblonganoside M (3), 3-O-β-D-glucopyranosyl- (1 → 2) -α-L-arabinopyranosyl 3β, 19α-dihydroxy-20α-urs-12-en-28 (4), woolly saponin B2 (5), ilexside II (6), rotundinoside B (7), ilekudinoside B (8), ilexpublesnin E (9), ilekudinoside D (10) and ilexpernoside D (11). Among them, compound 1 was a new δ-oleanolic triterpenoid saponin, and compounds 2-11 were isolated from this plant for the first time.