Sensitivity of the Pacific subtropical-tropical meridional cell to global warming is examined by using a global ocean-atmosphere coupled model developed at LASG/IAP. Results indicate that associated with the increasing of atmospheric carbon dioxide, the most prominent signals of global warming locate at high latitudes, and the change of middle and low latitudes, in particular the surface wind, is relatively weak, which leads to a weak response of the Pacific subtropical-tropical meridional cell. At the time of atmospheric carbon dioxide doubling, the change of the meridional cell strength is smaller than the amplitude of natural variability.