作者将热吸水链霉菌孢外酶一次性注入家兔和大鼠的气管内,诱导动物肺组织出现单核巨噬细胞渗出及细支气管炎、血管炎等病变。超微结构亦出现相应的变化。免疫荧光组化方法显示病变早期有血浆型纤维联接蛋白的渗出、其诱发的肺部病变特点为:①Ⅰ型肺泡细胞肿胀变性甚至坏死崩解,Ⅱ型肺泡细胞增生修复缺损并向扁平形被覆细胞过渡。②肺泡间隔毛细血管内皮细胞肿胀变性,胞浆内出现较多空泡甚至 In this study, we injected hot Streptomyces hygroscopicus into the trachea of ​​rabbits and rats and induced the exudation of mononuclear macrophages and bronchiolitis and vasculitis in the lungs of animals. The ultrastructure also appears corresponding changes. Immunofluorescence staining showed that there was exudation of plasma fibronectin in the early stage of the lesion. The characteristics of the lung lesions were as follows: ① I-type alveolar cells were swollen, degenerated or necrotic, the type Ⅱ alveolar cells were hyperplastic and repaired, Cell transition. ② alveolar septal capillary endothelial cell swelling and degeneration, there are more cytoplasm vacuoles or even