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内脏高敏感是功能性胃肠病(FGIDs)的核心发病机制。大量研究表明精神心理应激在内脏高敏感的发生、发展中起关键作用。大脑中枢是参与精神心理应激致内脏高敏感的关键部位,尤其是高级中枢致敏,但其具体病理生理机制尚待明确。本文就精神应激诱发内脏高敏感的中枢作用机制的研究作一综述。
Visceral hypersensitivity is a central pathogenesis of functional gastrointestinal diseases (FGIDs). A large number of studies have shown that mental stress plays a key role in the occurrence and development of visceral hypersensitivity. The brain center is involved in mental stress induced visceral hypersensitivity of the key parts, especially the high central sensitization, but its specific pathophysiological mechanisms remain to be clear. This article reviews the central mechanism of stress-induced visceral hypersensitivity.