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目的探讨蒙脱石散联合双歧杆菌乳杆菌三联活菌片治疗小儿腹泻的临床疗效。方法选取2014年3月至2015年3月江苏省如皋市郭园医院收治的130例腹泻患儿为研究对象,按随机数字表法将其分为对照组和观察组,各65例。对照组患儿给予蒙脱石散治疗,观察组患儿在对照组基础上给予双歧杆菌乳杆菌三联活菌片进行治疗,比较两组患儿临床症状改善时间、临床疗效及不良反应发生情况。结果观察组患儿退热时间、大便恢复正常时间、止泻时间均明显短于对照组,差异均有统计学意义(均P<0.05);1个疗程治疗结束后,观察组患儿治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论蒙脱石散联合双歧杆菌乳杆菌三联活菌片治疗小儿腹泻时,从肠道保护和抑菌两方面协同作用,临床疗效明显提高,可缩短治疗时间,且无明显毒副作用。
Objective To investigate the clinical efficacy of montmorillonite powder combined with Lactobacillus bifidum triple active viable tablet in children with diarrhea. Methods A total of 130 children with diarrhea who were treated in Guo Yuan Hospital, Rugao City, Jiangsu Province from March 2014 to March 2015 were selected as study subjects and divided into control group and observation group according to random number table. Children in the control group were treated with montmorillonite powder. The children in the observation group were treated with Lactobacillus bifidosis triplet viable on the basis of the control group. The clinical symptom improvement time, clinical efficacy and incidence of adverse reactions in both groups were compared . Results In the observation group, the antipyretic time, the normal time of stool recovery and the antidiarrheal time of the observation group were significantly shorter than those of the control group (all P <0.05); after one course of treatment, the treatment group The total effective rate was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusions Montmorillonite powder combined with Bifidobacterium Lactobacillus triple viable tablet can effectively reduce the treatment time and has no obvious side effects in the treatment of infantile diarrhea with synergistic effect of intestinal protection and bacteriostasis.