目前病原微生物的耐药性已成为国内、外学者们普遍关注的一个话题,而且新药的研发速度远远低于耐药性的产生速度。一种抗微生物新药经过高成本和长周期的漫长研发及全面的临床前评价后,往往在应用于临床不久就出现耐药菌,而且研究已经证实耐药性能够通过质粒介导由一种病原微生 At present, the resistance of pathogenic microorganisms has become a topic of widespread concern both at home and abroad, and the speed of research and development of new drugs is far lower than that of drug resistance. An antimicrobial drug often undergoes drug resistance soon after it has been clinically applied due to its long history of high cost, long cycle development and comprehensive preclinical evaluation. Studies have shown that drug resistance can be mediated by a plasmid Microbes