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强有力的流行病学证据表明,幽门弯曲菌(CP)可引起十二指肠溃疡(DU),但 CP 如何引起溃疡仍需进一步研究。最初认为,CP 所致的溃疡似乎与已确立的 DU 是由于胃泌素释放过多和胃酸分泌增加的观点是不一致的。本文为了检验一元化假说,即胃窦部的 CP 可增加胃泌素的释放从而使胃酸分泌增加。作者做了进餐刺激胃泌素释放试验、五肽胃泌素刺激胃酸分泌试验并对 DU 患者胃窦部有无 CP 存在进行了检查。病人和方法 31例患者未患与 DU 有关的疾病,也未作过胃或迷走神经切除手术,近3天未服 H_2受体拮抗剂,8周来也未服过三钾二枸橼酸络合铋
Strong epidemiological evidence shows that Campylobacter pylori (CP) can cause duodenal ulcer (DU), but how to cause ulcer ulcer CP still needs further study. Initially, it seems that the ulcer caused by CP appears to be inconsistent with the established DU that is due to excessive gastrin release and increased gastric acid secretion. In this paper, in order to test the unity of the hypothesis that the antrum of the CP can increase the release of gastrin so that gastric acid secretion increased. The authors did a meal to stimulate the gastrin release test, pentagastrin to stimulate the gastric acid secretion test and to examine the presence or absence of CP in the gastric antrum of DU patients. Patients and Methods Twenty-one patients did not have any disease related to DU and did not undergo gastric or vagotomy surgery. H_2 receptor antagonists were not given for nearly 3 days and did not take tripotassium citrate complex for 8 weeks bismuth